People

Principal Investigator

Staff Scientist
Recent work focuses on human antibody responses to influenza vaccines.

Postdoc
Studying the human B cell response, especially monoclonal antibody against neuraminidase to influenza virus.

PhD candidate
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PhD candidate
Karlynn is studying the gene expression profiles of plasmablasts induced 7 days post-influenza immunization. We hope to draw correlations between these profiles and the functional properties of the monoclonal antibody each cell produces.

PhD candidate
Chris is studying some of the mechanisms that underlie affinity maturation, specifically in regards to the targeting of activation-induced cytidine deaminase. By combining computational techniques and modeling with transgenic mice studies we hope to infer the functional importance and impact of these targeting mechanisms during the humoral immune response against both acute and chronic infections.

Research tech
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Research tech
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Research tech
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Research tech
Irvin is investigating the quality of human antibody responses to seasonal influenza and pneumoccocal vaccination. Our monoclonal antibody production pathway allows for the generation of large panels of antibodies from activated B cells, which are used to produce high-resolution binding and functional data. We hope to use this information to enhance our understanding of how the immune system responds to vaccines, and to improve the effectiveness of vaccination schedules.

Senior research project specialist
Karla provides clinical research support for the lab and is also working on a project on lupus erythematosus. She is comparing B cell population frequencies, monoclonal antibodies and cytokine profiles in SLE patients, healthy relatives and appropriate controls. Autoimmune clinical manifestations and autoreactive severity fluctuations will be compared to antibody avidity, altered B cell populations and cytokine patterns to provide further insights on the imbalance between protective and pathogenic function. Findings will enhance understanding of: autoimmune predisposition in relatives, B cell populations, SLE disease generation/prevention, antibody avidity and hopefully further exploration of targeted therapeutic approaches.

Alumni

Kaval Kaur (graduate student, 2010-2015)
Thesis: B cell responses to influenza in the context of autoimmunity
Current: Research Fellow, Singapore Immunology Network, A*STAR
Noel Pauli (graduate student, 2010-2015)
Thesis: The impact of Staphylococcus aureus infection on human B cells responses
Current: Scientist 1, Adimab, LLC
Sarah Andrews (postdoc, 2010-2014)
Current: Staff Scientist, NIH
Kristi A. Koelsch (graduate student, 2004-2009)
Thesis: Insights into the Regulation of Human B Cell Tolerance by Analysis of the Immunoglobulin Repertoire
Current: Assistant Professor of Research, Department of Endocrinology, University of Oklahoma Health Sciences Cluster
Qingzhao Zhang (graduate student, 2004-2009)
Thesis: Autoreactive Antibodies Can Persist in Allelically Included B Cells and Edited Cells are Selected at the Transitional Stage
Current: Lab and research specialist, Flow Cytometry Core Facility, Virginia Commonwealth University
Ken Smith (postdoc, 2006-2008)
Current: Research Assistant Member and Director of the OMRF Human Antibody Core Facility
J. Andrew Duty (Andy) (graduate student, 2003-2007)
Thesis:
Current: Assistant Research Professor, Department of Microbiology, Center for Therapeutic Antibody Development, Icahn School of Medicine at Mt. Sinai
Last modified: May 5, 2017